资讯与服务

    (周一至周日 9:00-21:00)
    微信:liu87712531
    微信:lin445385978

    邮箱:87712531@qq.com

    咨询电话:15321970583

网站服务

您当前位置:首页 -> 英语论文 -> 英语其它相关->详细(目前国内最大最全原创最多的免费论文中心)

客服QQ咨询:点击这里给我发消息 点击这里给我发消息

无忧论文,为您指导,让您轻松发表,轻松晋级!

字号大小:


The Influence of Endocrine Effects of Adjuvant Therapy on Quality of Life Outcomes in Younger Breast Cancer Survivors(一)

作者:来来来 整理:本网站论文网 录入时间:2011-12-13 23:15:34

  【关键词】 Breast,cancer,•,Fertility,•,Gonadal,toxicity,•,Menopause,•,Quality,of,life

  LEARNING OBJECTIVES

  After completing this course, the reader will be able to:

  Identify risk factors for amenorrhea by age for young women treated with adjuvant chemotherapy.

  Describe the associated quality of life outcomes with premature menopause as a sequelae of cancer therapy.

  Discuss the safety and efficacy of fertility preservation options for women with breast cancer.

  ABSTRACT

  

  Significance. There are 2.2 million breast cancer survivors, and approximately 25%30% of newly diagnosed women each year are <50 years of age. Adjuvant therapy has prolonged survival, but the quality of that survival is influenced by persistent and late effects of therapy. Knowledge of treatment outcomes will assist in the design of interventions to prevent or manage persistent and late effects in survivors.

  Purpose. The purpose of this paper is to review the incidence of gonadal toxicity associated with adjuvant chemotherapy, side effects of endocrine therapy, quality of life outcomes, fertility concerns, and options to preserve fertility in young (<35 years) and young midlife (3550 years) breast cancer survivors.

  Results. Alkylating agentbased chemotherapy causes destruction of primordial follicles and impairment of follicular maturation resulting in temporary preservation of menses, reversible amenorrhea, irregular menses (perimenopause), or irreversible amenorrhea (ovarian failure―menopause). Younger women have a lower risk for amenorrhea with chemotherapy because of sufficient follicular stores, although the gonadal toxicity will result in an earlier than expected menopause. Premature menopause is associated with poorer quality of life, decreased sexual functioning, menopausal symptom distress, psychosocial distress related to fertility concerns, infertility, and uncertainty about late effects of premature menopause. Routine discussion about the menopausal experience, risks for infertility, and fertility preservation options is recommended.

  Implications for Practice. This review identified adverse treatment outcomes for young and young midlife breast cancer survivors that can be minimized or prevented with targeted interventions.

  INTRODUCTION

  

  There are 2.2 million breast cancer survivors, and approximately 25%30% of newly diagnosed women each year are <50 years of age. With the lower mortality and longer survival time resulting from adjuvant therapy [1], chemotherapy or endocrine therapy may be recommended to women <50 years of age, depending on the stage, prognostic factors, and hormone sensitivity of the tumor. Late effects of adjuvant therapy were identified more than a decade ago [2], and the impact of persistent and late effects of cancer treatment on survivors has gained national and international attention [3, 4]. Youn

首页 上一页 1 2 3 4 5 6 7 下一页 尾页 1/12/12

上一篇APEC Summit in Shanghai
下一篇Overview of what is a bond and ..